Successful Treatment of Refractory Autoimmune Hepatitis With Rituximab
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چکیده
Autoimmune hepatitis is a severe liver disease in which ∼10% of patients do not respond to standard treatment. We describe a new rescue therapy using anti-CD20 monoclonal antibodies (rituximab). Complete remission was obtained and maintained by using low doses of immunosuppressive drugs with repeated anti-CD20 infusions. Pediatrics 2013;132:e526–e530 AUTHORS: Daniel D’Agostino, MD,a Alejandro Costaguta, MD,b and Fernando Álvarez, MDc aPediatric Gastroenterology-Hepatology Division, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; bUnidad de Hígado y Trasplante Hepático, Sanatorio de Niños, Rosario, Argentina; and cPédiatrie, CHU Sainte-Justine Université de Montréal, Montreal, Canada
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Autoimmune hepatitis is a severe liver disease in which ~10% of patients do not respond to standard treatment. We describe a new rescue therapy using anti-CD20 monoclonal antibodies (rituximab). Complete remission was obtained and maintained by using low doses of immunosuppressive drugs with repeated anti-CD20 infusions.
متن کاملSuccessful Treatment of Refractory Autoimmune Hepatitis With Rituximab
Autoimmune hepatitis is a severe liver disease in which ∼10% of patients do not respond to standard treatment. We describe a new rescue therapy using anti-CD20 monoclonal antibodies (rituximab). Complete remission was obtained and maintained by using low doses of immunosuppressive drugs with repeated anti-CD20 infusions. Pediatrics 2013;132:e526–e530 AUTHORS: Daniel D’Agostino, MD,a Alejandro C...
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